10 Facts About Combination chemotherapy

Era of cancer Combination chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs.

Beginnings of the modern era of cancer chemotherapy can be traced directly to the German introduction of chemical warfare during World War I Among the chemical agents used, mustard gas was particularly devastating.

Combination chemotherapy then decided to try to develop anti-metabolites in the same way as Farber, by making small changes in a metabolite needed by a cell to divide.

James F Holland, Emil Freireich, and Emil Frei hypothesized that cancer chemotherapy should follow the strategy of antibiotic therapy for tuberculosis with combinations of drugs, each with a different mechanism of action.

Combination chemotherapy observed that the bacteria unexpectedly ceased to divide when placed in an electric field.

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Combination chemotherapy was disappointed to find that the cause was an experimental artifact — the inhibition of bacterial division was pinpointed to an electrolysis product of the platinum electrode rather than the electrical field.

The patient's bone marrow was first harvested, the Combination chemotherapy administered, and the harvested marrow then returned to patient a few days later.

The proven curative benefits of high doses of chemotherapy afforded by autologous bone marrow rescue are limited to both Hodgkin's and selected non-Hodgkin's lymphoma patients who have failed therapy with conventional combination chemotherapy.

Combination chemotherapy reasoned that precisely inhibiting this kinase with a drug would control the disease and have little effect on normal cells.

Nonetheless, cancer remains a major cause of illness and death, and conventional cytotoxic Combination chemotherapy has proved unable to cure most cancers after they have metastasized.