32 Facts About Crohn's disease

People with Crohn's disease are susceptible to Angular Stomatitis, an inflammation of the corners of the mouth, and Pyostomatitis Vegetans.

Crohn's disease can affect many organ systems beyond the gastrointestinal tract.

Amyloidosis secondary to Crohn's disease has been described and is known to affect the kidneys.

Crohn's disease is associated with a type of rheumatologic disease known as seronegative spondyloarthropathy.

Crohn's disease is linked to many psychological disorders, including depression and anxiety, denial of your disease, the need for dependence or dependent behaviors, feeling overwhelmed, and having a poor self-image.

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People with Crohn's disease often have issues with small bowel bacterial overgrowth syndrome, which can produce micronutrient deficiencies.

For example, individuals with Crohn's disease involving the small bowel are at higher risk for small intestinal cancer.

Some studies suggest there is a role for chemoprotection in the prevention of colorectal cancer in Crohn's disease involving the colon; two agents have been suggested, folate and mesalamine preparations.

Individuals with Crohn's disease are at risk of malnutrition for many reasons, including decreased food intake and malabsorption.

Crohn's disease can be problematic during pregnancy, and some medications can cause adverse outcomes for the fetus or mother.

Crohn's disease likely has involvement of both the adaptive and innate immune systems.

Crohn's disease can be described as a multifactorial autoinflammatory disease.

However, in Crohn's disease, NOD2 mutations act as a risk factor, being more common among Crohn's disease patients than the background population, while in Blau's disease NOD2 mutations are linked directly to this syndrome, as it is an autosomal-dominant disease.

All this new knowledge in the pathogenesis of Crohn's disease allows us to put this multifactorial disease in the group of autoinflammatory syndromes.

Crohn's disease is associated with an increased intake of animal protein, milk protein, and an increased ratio of omega-6 to omega-3 polyunsaturated fatty acids.

The granulomas of Crohn's disease do not show "caseation", a cheese-like appearance on microscopic examination characteristic of granulomas associated with infections, such as tuberculosis.

However, individuals affected by the Crohn's disease rarely fall outside these three classifications, with presentations in other areas.

Penetrating Crohn's disease creates abnormal passageways between the bowel and other structures, such as the skin.

Celiac Crohn's disease cannot be excluded if specific antibodies are negative, nor in absence of intestinal villi atrophy.

Treatment for Crohn's disease involves first treating the acute problem and its symptoms, then maintaining remission of the disease.

Medications used to treat the symptoms of Crohn's disease include 5-aminosalicylic acid formulations, prednisone, immunomodulators such as azathioprine, methotrexate, and anti-TNF therapies and monoclonal antibodies, such as infliximab, adalimumab, certolizumab, vedolizumab, ustekinumab, and natalizumab.

Crohn's disease lesions are nearly always found at the site of the resected bowel.

Mild postsurgical recurrences of Crohn's disease are graded i1 and i2, moderate to severe recurrences are graded i3 and i4.

Crohn's disease is a chronic condition for which there is no known cure.

However, Crohn's disease is associated with a small increase in risk of small bowel and colorectal carcinoma .

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Percentage of people with Crohn's disease has been determined in Norway and the United States and is similar at 6 to 7.

Crohn's disease is more common in northern countries, and with higher rates still in the northern areas of these countries.

The incidence of Crohn's disease is thought to be similar in Europe but lower in Asia and Africa.

Crohn's disease begins most commonly in people in their teens and 20s, and people in their 50s through to their 70s.

Parents, siblings or children of people with Crohn's disease are 3 to 20 times more likely to develop the disease.

Incidence of Crohn's disease is increasing in Europe and in newly industrialised countries.

Crohn's disease is common in parts of the world where helminthic colonisation is rare and uncommon in those areas where most people carry worms.