Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol.
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16 Facts About Cushing's syndrome
2.
Cushing's syndrome is caused by either excessive cortisol-like medication, such as prednisone, or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands.
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3.
Cushing's syndrome was first described by American neurosurgeon Harvey Cushing in 1932.
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4.
Many of the features of Cushing's are those seen in metabolic syndrome, including insulin resistance, hypertension, obesity, and elevated blood levels of triglycerides.
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5.
When Cushing's syndrome is caused by an increase of cortisol at the level of the adrenal glands, negative feedback ultimately reduces ACTH production in the pituitary.
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Harvey Cushing6.
Cushing's disease is a specific type of Cushing's syndrome caused by a pituitary tumor leading to excessive production of ACTH .
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7.
Rarely, Cushing's syndrome can be due to the use of medroxyprogesterone acetate.
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8.
One of the causes of Cushing's syndrome is a cortisol-secreting adenoma in the cortex of the adrenal gland .
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9.
Cushing's syndrome disease refers only to hypercortisolism secondary to excess production of ACTH from a corticotroph pituitary adenoma or due to excess production of hypothalamus CRH .
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10.
When Cushing's syndrome is due to extra ACTH it is known as ectopic Cushing syndrome.
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11.
When Cushing's syndrome is suspected, either a dexamethasone suppression test, or a 24-hour urinary measurement for cortisol offers equal detection rates.
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12.
Cushing's syndrome can be ascertained via a variety of test which include the following:.
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13.
Cushing's syndrome caused by treatment with corticosteroids is the most common form.
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14.
Cushing's syndrome disease is rare; a Danish study found an incidence of less than one case per million people per year.
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15.
People with Cushing's syndrome have increased morbidity and mortality as compared to the general population.
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16.
People with Cushing's syndrome have nearly 4 times increased cardiovascular mortality as compared to the general population.
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