Diabetic neuropathy refers to various types of nerve damage associated with diabetes mellitus.
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Diabetic neuropathy refers to various types of nerve damage associated with diabetes mellitus.
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Diabetic neuropathy can affect any peripheral nerves including sensory neurons, motor neurons, and the autonomic nervous system.
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Therefore, diabetic neuropathy has the potential to affect essentially any organ system and can cause a range of symptoms.
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Diabetic peripheral neuropathy can be diagnosed with a history and physical examination.
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The most useful physical examination finding for large fiber Diabetic neuropathy is an abnormally decreased vibration perception to a 128-Hz tuning fork or pressure sensation with a 5.
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Small fiber neuropathy measured by QST and Sudomotor function tests, through electrochemical skin conductance, is more and more indicated to assess early signs of diabetic neuropathy and autonomic neuropathy.
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Diabetic neuropathy encompasses a series of different neuropathic syndromes which can be categorized as follows:.
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Diabetic neuropathy can be largely prevented by maintaining blood glucose levels and lifestyle modifications.
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Only three medications approved by the United States' Food and Drug Administration for diabetic peripheral neuropathy are the antidepressant duloxetine, the anticonvulsant pregabalin, and the long-acting opioid tapentadol ER.
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At low dosages used for Diabetic neuropathy, toxicity is rare, but if symptoms warrant higher doses, complications are more common.
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Diabetes is the leading known cause of Diabetic neuropathy in developed countries, and Diabetic neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes.
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The progression of Diabetic neuropathy is dependent on the degree of glycemic control in both Type 1 and Type 2 diabetes.
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