27 Facts About Diazepam

Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic.

Diazepam is mainly used to treat anxiety, insomnia, panic attacks and symptoms of acute alcohol withdrawal.

Diazepam is the most commonly used benzodiazepine for "tapering" benzodiazepine dependence due to the drug's comparatively long half-life, allowing for more efficient dose reduction.

Diazepam gel was better than placebo gel in reducing the risk of non-cessation of seizures.

Diazepam is rarely used for the long-term treatment of epilepsy because tolerance to its anticonvulsant effects usually develops within six to 12 months of treatment, effectively rendering it useless for that purpose.

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Diazepam is used for the emergency treatment of eclampsia, when IV magnesium sulfate and blood-pressure control measures have failed.

Diazepam is marketed in over 500 brands throughout the world.

Diazepam has a range of side effects common to most benzodiazepines, including:.

Diazepam is therefore only recommended for short-term therapy at the lowest possible dose owing to risks of severe withdrawal problems from low doses even after gradual reduction.

Diazepam is a good choice for tapering for those using high doses of other benzodiazepines since it has a long half-life thus withdrawal symptoms are tolerable.

Diazepam is not the only drug to target these GABAA receptors.

Diazepam appears to act on areas of the limbic system, thalamus, and hypothalamus, inducing anxiolytic effects.

Diazepam can be administered orally, intravenously, intramuscularly, or as a suppository.

Diazepam is highly lipid-soluble, and is widely distributed throughout the body after administration.

Diazepam is stored preferentially in some organs, including the heart.

Diazepam undergoes oxidative metabolism by demethylation, hydroxylation and glucuronidation in the liver as part of the cytochrome P450 enzyme system.

Diazepam has a biphasic half-life of about one to three days, and two to seven days for the active metabolite desmethyldiazepam.

Diazepam occurs as solid white or yellow crystals with a melting point of 131.

Diazepam can absorb into plastics, so liquid preparations should not be kept in plastic bottles or syringes, etc.

Diazepam was the second benzodiazepine invented by Leo Sternbach of Hoffmann-La Roche at the company's Nutley, New Jersey, facility following chlordiazepoxide, which was approved for use in 1960.

Diazepam is a medication with a high risk of misuse and can cause drug dependence.

Diazepam has been shown to be able to substitute for the behavioural effects of barbiturates in a primate study.

Diazepam is regulated in most countries as a prescription drug:.

Diazepam is a Schedule IV controlled drug under the Convention on Psychotropic Substances.

Diazepam is Schedule 4 substance under the Poisons Standard.

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Diazepam is controlled as a Schedule IV substance under the Controlled Substances Act of 1970.

Diazepam is used as a short-term sedative and anxiolytic for cats and dogs, sometimes used as an appetite stimulant.