DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune response.
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15 Facts About DNA vaccine
2.
The DNA vaccine is injected into the body and taken up by cells, whose normal metabolic processes synthesize proteins based on the genetic code in the plasmid that they have taken up.
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3.
The NIH DNA vaccine is injected into the upper arm under high pressure.
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4.
DNA vaccine immunization is being investigated as a means of developing antivenom sera.
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5.
Gene gun delivery ballistically accelerates plasmid DNA vaccine that has been absorbed onto gold or tungsten microparticles into the target cells, using compressed helium as an accelerant.
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6.
DNA vaccine-raised antibody responses rise much more slowly than when natural infection or recombinant protein immunization occurs.
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7.
Additionally, the titres of specific antibodies raised by DNA vaccine vaccination are lower than those obtained after vaccination with a recombinant protein.
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8.
In other words, DNA vaccine immunization induces a qualitatively superior response.
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9.
Two theories dominate – that in vivo uptake of DNA vaccine occurs non-specifically, in a method similar to phago- or pinocytosis, or through specific receptors.
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10.
DNA vaccine vaccination generates an effective immune memory via the display of antigen-antibody complexes on follicular dendritic cells, which are potent B-cell stimulators.
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11.
An effective DNA vaccine must induce an appropriate immune response for a given pathogen.
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12.
Plasmid DNA vaccine itself appears to have an adjuvant effect on the immune system.
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13.
DNA vaccine-primed immune responses can be boosted by the administration of recombinant protein or recombinant poxviruses.
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14.
Priming with DNA vaccine focuses the immune response on the required immunogen, while boosting with the recombinant virus provides a larger amount of expressed antigen, leading to a large increase in specific CTL responses.
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15.
Such DNA vaccine-coated microparticles can be as effective at raising CTL as recombinant viruses, especially when mixed with alum.
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