15 Facts About Doxepin

Doxepin is a medication used to treat major depressive disorder, anxiety disorders, chronic hives, and insomnia.

Doxepin was approved for medical use in the United States in 1969.

Doxepin is used as a pill to treat major depressive disorder, anxiety disorders, and chronic hives, and for short-term help with trouble remaining asleep after going to bed.

Doxepin is secreted in breast milk and neonatal cases of respiratory depression in association with maternal doxepin use have been reported.

Doxepin is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin–norepinephrine reuptake inhibitor, and has additional antiadrenergic, antihistamine, antiserotonergic, and anticholinergic activities.

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Doxepin is a potent blocker of voltage-gated sodium channels, and this action is thought to be involved in both its lethality in overdose and its effectiveness as an analgesic.

Doxepin is a mixture of and stereoisomers with an approximate ratio of 85:15.

Doxepin is a highly potent antihistamine, with this being its strongest activity.

Doxepin is extensively metabolized by the liver via oxidation and N-demethylation.

Doxepin is a tricyclic compound, specifically a dibenzoxepin, and possesses three rings fused together with a side chain attached in its chemical structure.

Doxepin is a tertiary amine TCA, with its side chain-demethylated metabolite nordoxepin being a secondary amine.

Doxepin is a mixture of and stereoisomers and is used commercially in a ratio of approximately 85:15.

Doxepin was discovered in Germany in 1963 and was introduced in the United States as an antidepressant in 1969.

Doxepin is the generic name of the drug in English and German and its INN and BAN, while doxepin hydrochloride is its USAN, USP, BANM, and JAN.

Doxepin was under development by Winston Pharmaceuticals in an intranasal formulation for the treatment of headache.