Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer.
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11 Facts About Doxorubicin
2.
Doxorubicin is in the anthracycline and antitumor antibiotic family of medications.
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4.
Doxorubicin hydrochloride is indicated to treat breast cancer in combination with cyclophosphamide.
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5.
Doxorubicin is commonly used to treat some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others.
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6.
Doxorubicin-induced cardiomyopathy typically results in dilated cardiomyopathy, with all four cardiac chambers being enlarged.
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7.
Doxorubicin is a 14-hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway.
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8.
Doxorubicin's group cloned many of the genes required for DXR production, although not all of them have been fully characterized.
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9.
Doxorubicin showed better activity than daunorubicin against mouse tumors, and especially solid tumors.
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10.
Doxorubicin is available in liposome-encapsulated forms as Doxil, Myocet, and Caelyx, which are given by intravenous injection.
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11.
Doxorubicin fluorescence is quenched by binding to DNA, and shielded by micelle encapsulation.
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