15 Facts About Flu vaccine

In certain years, the Flu vaccine was linked to an increase in Guillain–Barre syndrome among older people at a rate of about one case per million doses.

The live, weakened Flu vaccine is generally not recommended in pregnant women, children less than two years old, adults older than 50, or people with a weakened immune system.

Human Flu vaccine is meant unless specifically identified as a veterinary, poultry or livestock Flu vaccine.

Quadrivalent flu vaccine administered by nasal mist was approved by the FDA in March 2012.

The flu vaccine can reduce the severity of the flu if a person contracts a strain that the vaccine did not contain.

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However, in most years, the flu vaccine strains have been a good match for the circulating strains, and even a mismatched vaccine can often provide cross-protection.

In children, the vaccine appears to decrease the risk of influenza and possibly influenza-like illness.

Available evidence indicates that vaccinating the elderly with the high-dose vaccine leads to a stronger immune response against influenza than the regular-dose vaccine.

Flu vaccine containing an adjuvant was approved by the US Food and Drug Administration in November 2015, for use by adults aged 65 years of age and older.

Flu vaccine is contraindicated for those under six months of age and those with severe, life-threatening allergies to flu vaccine or any ingredient in the vaccine.

Until 2021, the egg-based Flu vaccine has been the only one available, but from March 2021 a new cell-based Flu vaccine is available for those who wish to pay for it, and it is expected that this one will become the standard by 2026.

Gene-based DNA Flu vaccine, used to prime the immune system after boosting with an inactivated H5N1 Flu vaccine, underwent clinical trials in 2011.

Audenz is a vaccine indicated for active immunization for the prevention of disease caused by the influenza A virus H5N1 subtype contained in the vaccine.

The oral Flu vaccine candidate is based on an adenovirus type5 vector modified to remove genes needed for replication, with an added gene that expresses a small double-stranded RNA hairpin molecule as an adjuvant.

In 2020, a PhaseII human trial of the pill form of the Flu vaccine showed that it was well tolerated and provided similar immunity to a licensed injectable Flu vaccine.