14 Facts About Fluoxetine

Fluoxetine, sold under the brand names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor class.

Fluoxetine taken during pregnancy is associated with significant increase in congenital heart defects in the newborns.

Fluoxetine was discovered by Eli Lilly and Company in 1972, and entered medical use in 1986.

Fluoxetine is frequently used to treat major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder, bulimia nervosa, panic disorder, premenstrual dysphoric disorder, and trichotillomania.

Fluoxetine is as effective as tricyclic antidepressants but is better tolerated.

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Fluoxetine is used to treat premenstrual dysphoric disorder, a condition where individuals have affective and somatic symptoms monthly during the luteal phase of menstruation.

Fluoxetine is considered a first-line medication for the treatment of impulsive aggression of low intensity.

Fluoxetine reduced low intensity aggressive behavior in patients in intermittent aggressive disorder and borderline personality disorder.

Fluoxetine reduced acts of domestic violence in alcoholics with a history of such behavior.

Fluoxetine can affect the electrical currents that heart muscle cells use to coordinate their contraction, specifically the potassium currents Ito and IKs that repolarise the cardiac action potential.

Fluoxetine has been shown to inhibit acid sphingomyelinase, a key regulator of ceramide levels which derives ceramide from sphingomyelin.

Fluoxetine is metabolized in the liver by isoenzymes of the cytochrome P450 system, including CYP2D6.

Fluoxetine has been detected in aquatic ecosystems, especially in North America.

Fluoxetine affects both aquacultured invertebrates and vertebrates, and inhibits soil microbes including a large antibacterial effect.