14 Facts About Fluoxetine


Fluoxetine, sold under the brand names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor class.

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Fluoxetine taken during pregnancy is associated with significant increase in congenital heart defects in the newborns.

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Fluoxetine was discovered by Eli Lilly and Company in 1972, and entered medical use in 1986.

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Fluoxetine is frequently used to treat major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder, bulimia nervosa, panic disorder, premenstrual dysphoric disorder, and trichotillomania.

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Fluoxetine is as effective as tricyclic antidepressants but is better tolerated.

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Fluoxetine is used to treat premenstrual dysphoric disorder, a condition where individuals have affective and somatic symptoms monthly during the luteal phase of menstruation.

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Fluoxetine is considered a first-line medication for the treatment of impulsive aggression of low intensity.

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Fluoxetine reduced low intensity aggressive behavior in patients in intermittent aggressive disorder and borderline personality disorder.

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Fluoxetine reduced acts of domestic violence in alcoholics with a history of such behavior.

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Fluoxetine can affect the electrical currents that heart muscle cells use to coordinate their contraction, specifically the potassium currents Ito and IKs that repolarise the cardiac action potential.

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Fluoxetine has been shown to inhibit acid sphingomyelinase, a key regulator of ceramide levels which derives ceramide from sphingomyelin.

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Fluoxetine is metabolized in the liver by isoenzymes of the cytochrome P450 system, including CYP2D6.

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Fluoxetine has been detected in aquatic ecosystems, especially in North America.

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Fluoxetine affects both aquacultured invertebrates and vertebrates, and inhibits soil microbes including a large antibacterial effect.

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