10 Facts About Fluvoxamine


Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor class.

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Fluvoxamine is approved in the United States for OCD, and social anxiety disorder.

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Fluvoxamine is effective for GAD, social anxiety disorder, panic disorder and separation anxiety disorder in children and adolescents.

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Fluvoxamine has been observed to increase serum concentrations of mirtazapine, which is mainly metabolized by CYP1A2, CYP2D6, and CYP3A4, by three- to four-fold in humans.

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Fluvoxamine seriously affects the pharmacokinetics of tizanidine and increases the intensity and duration of its effects.

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Fluvoxamine is a potent selective serotonin reuptake inhibitor with around 100-fold affinity for the serotonin transporter over the norepinephrine transporter.

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Fluvoxamine was developed by Kali-Duphar, part of Solvay Pharmaceuticals, Belgium, now Abbott Laboratories, and introduced as Floxyfral in Switzerland in 1983.

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Fluvoxamine was the first SSRI to be registered for the treatment of obsessive compulsive disorder in children by the FDA in 1997.

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Fluvoxamine was the first SSRI approved for clinical use in the United Kingdom.

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Fluvoxamine is a common finding in waters near human settlement.

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