1. Until the age of 22, Acerbi played only in the lower tiers of Italian football, before being purchased by the Serie B club Reggina, where he established himself as a starting lineup defender.

1. Until the age of 22, Acerbi played only in the lower tiers of Italian football, before being purchased by the Serie B club Reggina, where he established himself as a starting lineup defender.
In 2011, Francesco Acerbi signed with Chievo, thus making his Serie A debut.
In 2018, having made 173 appearances in all competitions for the Neroverdi, Francesco Acerbi transferred to Lazio, where he continued to be a starting defender.
An Italian international since 2014, Francesco Acerbi played for the national team on three occasions in friendly games before making his competitive debut in 2019, later taking part in his nation's victorious UEFA Euro 2020 campaign.
Francesco Acerbi was then loaned to Serie D team Renate on 11 January 2007 and played a club friendly on the same day.
Francesco Acerbi was suspended in the next cup match and was not included in the third round.
In 2019, Francesco Acerbi revealed that during his time in Milan he suffered from depression, grieving the death of his father, and often relied on alcohol to quell his emotional pain.
Francesco Acerbi subsequently underwent chemotherapy from 7 January to 14 March 2014.
On 11 July 2018, Francesco Acerbi joined Lazio on a five-year contract.
Francesco Acerbi was set to catch up to the record of 162 consecutive Serie A appearances by an outfield player, held by Javier Zanetti.
Francesco Acerbi's personal run started on 18 October 2015, when he was still a Sassuolo player.
On 1 September 2022, Francesco Acerbi moved on loan to Inter Milan.
On 10 August 2012, Francesco Acerbi received his first senior team call-up from Cesare Prandelli.