10 Facts About Hydromorphone

Hydromorphone, known as dihydromorphinone, and sold under the brand name Dilaudid among others, is an opioid used to treat moderate to severe pain.

Hydromorphone is believed to work by activating opioid receptors, mainly in the brain and spinal cord.

Hydromorphone and related opioids produce their major effects on the central nervous system and gastrointestinal tract.

Hydromorphone is available in parenteral, rectal, subcutaneous, and oral formulations, and can be administered via epidural or intrathecal injection.

Hydromorphone has been administered via nebulization to treat shortness of breath, but it is not used as a route for pain control due to low bioavailability.

Related searches

Hydromorphone is extensively metabolized in the liver to hydromorphone-3-glucoronide, which has no analgesic effects.

Hydromorphone is made from morphine either by direct re-arrangement or reduction to dihydromorphine (usually via catalytic hydrogenation), followed by oxidation with benzophenone in presence of potassium tert butoxide or aluminium tert butoxide (Oppenauer oxidation).

Hydromorphone is made from morphine via catalytic hydrogenation and is produced in trace amounts by human and other mammalian metabolisms of morphine.

Hydromorphone is known in various countries around the world by the brand names Hydal, Dimorphone, Exalgo, Sophidone LP, Dilaudid, Hydrostat, Hydromorfan, Hydromorphan, Hymorphan, Laudicon, Opidol, Palladone, Hydromorph Contin, and others.

Hydromorphone is listed under the German Betaubungsmittelgesetz as a Betaubungsmittel in the most restricted schedule for medicinal drugs; it is controlled similarly in Austria under the SMG and the Swiss BetmG.