1. John Ioannidis has served on the editorial board of over twenty scientific journals including Journal of the American Medical Association, Journal of the National Cancer Institute and The Lancet.
49 Facts About John Ioannidis
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John Ioannidis was a prominent opponent of lockdowns during the COVID-19 pandemic, and he has been accused of promoting conspiracy theories about COVID-19 policies and public health and safety measures.
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John Ioannidis was valedictorian of his class at Athens College, graduating in 1984, and won a number of awards, including the National Award of the Greek Mathematical Society.
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John Ioannidis graduated in the top rank of his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine.
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John Ioannidis did a fellowship at Tufts University for infectious disease and received a PhD in biopathology at the University of Athens.
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John Ioannidis is a very highly cited medical researcher, with an h-index of 239 on Google Scholar in January 2023.
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From 1998 to 2010, John Ioannidis was chairman of the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine.
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John Ioannidis has been president of the Society for Research Synthesis Methodology.
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John Ioannidis holds four academic appointments at Stanford University: Professor of Medicine, Professor of Epidemiology and Population Health, Professor of Statistics and Professor of Biomedical Data Science.
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John Ioannidis is director of the Stanford Prevention Research Center, and co-director, along with Steven N Goodman, of the Meta-Research Innovation Center at Stanford.
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John Ioannidis has described the replication crisis in diverse scientific fields including genetics, clinical trials, neuroscience, and nutrition.
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John Ioannidis's work has aimed to identify solutions to problems in research, and on how to perform research more optimally.
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Thomas Trikalinos and John Ioannidis coined the term Proteus phenomenon to describe tendency for early studies on a subject to find larger effect than later ones.
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John Ioannidis was an early and influential public critic of Theranos, the now-fallen Silicon Valley blood test startup that at its height was valued at up to $9 billion.
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John Ioannidis criticized it for "stealth research" that it had not made available for other scientists to review.
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John Ioannidis has defined meta-research to include "thematic areas of methods, reporting, reproducibility, evaluation, and incentives ".
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John Ioannidis has performed large-scale assessments of the presence of reproducible and transparent research indicators such as data sharing, code sharing, protocol registration, declaration of funding and conflicts of interest in biomedical sciences, social sciences, and psychology.
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John Ioannidis has co-authored the Manifesto for Reproducible Science, an eight-page document illuminating the need to fix the flaws in the current scientific process and mitigate the "reproducibility crisis" in science.
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In "Why Most Published Research Findings are False", John Ioannidis focused on why most published research findings cannot be validated.
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John Ioannidis was invited to present his findings as a keynote speaker at the "Evidence Live 2016" conference, hosted jointly by the Centre for Evidence-Based Medicine at the Nuffield Department of Primary Care Health Sciences, University of Oxford and the BMJ.
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John Ioannidis has developed and popularized several methods for meta-analysis and has made several conceptual advances in this field.
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John Ioannidis has alerted about the misuse and misinterpretation of bias tests.
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John Ioannidis has been critical of flawed, misleading and redundant meta-analyses, estimating that few meta-analyses in medicine are both bias-free and clinically useful.
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John Ioannidis has performed empirical evaluations of the concordance of results between meta-analyses and large trials and between randomized trials and non-randomized studies.
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John Ioannidis has been one of the strong proponents and earlier advocates of evidence-based medicine.
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John Ioannidis has described four inter-related problems that create what he calls the Medical Misinformation Mess:.
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John Ioannidis has supported these views by contributing to a meta-epidemiological study which found that only 1 in 20 interventions tested in Cochrane Reviews have benefits that are supported by high-quality evidence and a related study showing that the quality of this evidence does not seem to improve over time.
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John Ioannidis has made methodological and conceptual contributions to the debates surrounding the use and misuse of statistical methods and inference.
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John Ioannidis has been an advocate of the approach to redefine statistical significance by requesting more stringent statistical significance thresholds; he has proposed and empirically validated stringent thresholds for genome-wide significance in genetics; and has been critical of the approach to entirely abandon statistical significance.
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John Ioannidis has contributed to several influential guidelines for reporting different types of research, such as PRISMA for meta-analyses, TRIPOD for multivariable prognostic and diagnostic models, and others on clinical trials and observational research.
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John Ioannidis is the lead author of the CONSORT for harms, a guideline that provides guidance on how to properly report on harms in randomized trials and has contributed to PRISMA for harms, a guideline for reporting of harms in meta-analyses.
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John Ioannidis was one of the first to advocate the use of meta-analysis in genetic epidemiology to assess replication and the incorporation of meta-analysis in large-scale consortia of multiple investigators performing genome-wide association studies.
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John Ioannidis led and contributed to many such efforts in diverse areas of genetic epidemiology and in other areas of molecular epidemiology.
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John Ioannidis has been critical of nutritional epidemiology research practices and has recommended reforms to improve the credibility of research in the field.
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John Ioannidis co-authored the DIETFITS randomized trial that showed no difference between a low-fat and a low-carb diet.
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John Ioannidis has advocated for the use of large national population databases with systematically collected data to minimize bias and improve yield of trustworthy discoveries.
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John Ioannidis has worked on the potential uses of such approaches in big data and artificial intelligence.
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John Ioannidis has performed critical assessments of the evidence behind mental health interventions.
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John Ioannidis co-authored a network meta-analysis on more than 500 randomized trials of anti-depressants showing a modest benefit from these medications for major depression.
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John Ioannidis has identified the potential for sponsorship bias in meta-analyses in mental health and has empirically assessed the totality of meta-analyses on mental health interventions, estimating that beneficial effects do exist, but they tend to be modest and thus a research agenda is needed to identify more effective interventions.
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The virus in fact eventually became widely disseminated, and would cause more than one million deaths in the US John Ioannidis expressed doubt that vaccines or treatments would be developed and tested in time to affect how the pandemic would unfold.
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In March 2020, John Ioannidis tried to organize a meeting at the White House where he and colleagues would caution President Donald Trump against "shutting down the country for [a] very long time and jeopardizing so many lives in doing this", according to a proposal he submitted.
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John Ioannidis widely promoted a study of which he had been co-author, "COVID-19 Antibody Seroprevalence in Santa Clara County, California", released as a preprint on April 17,2020.
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John Ioannidis concluded from the study that the coronavirus is "not the apocalyptic problem we thought".
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John Ioannidis has promoted the idea that there were financial incentives to put COVID-19 on death certificates and as such, they were unreliable during the pandemic, as well as the idea that doctors killed COVID-19 patients through premature intubations.
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Amid controversy over his COVID-19 work and his frequent televised interviews, John Ioannidis was harassed in memes and emails, including one falsely claiming his mother died of COVID-19.
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In February 2022 John Ioannidis co-authored a paper examining the role of indoor and outdoor air quality in the spread of SARS-CoV-2, which concluded that environmental health may be a crucial component in the prevention of COVID-19 and suggested preventive measures such as indoor CO2 monitoring and mechanical ventilation.
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The BMJ published responses to his paper, including a comment by Gavin Yamey, David Gorski, and Gideon Meyerowitz-Katz which argued that John Ioannidis's paper featured "factual errors, statistical shortcomings, failure to protect the named research subjects from harm, and potentially undeclared conflicts of interest that entirely undermine the analysis presented".
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John Ioannidis has received elected membership to the National Academy of Medicine, the European Academy of Sciences and Arts, the European Academy of Cancer Sciences, the American Epidemiological Society and the Association of American Physicians.