Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia.
| FactSnippet No. 591,660 |
17 Facts About Ketamine
2.
Ketamine is simple to administer and highly tolerable compared to drugs with similar effects which are flammable, irritating, or even explosive.
| FactSnippet No. 591,661 |
3.
Ketamine is a novel compound, derived from PCP, created in pursuit of a safer anesthetic with similar characteristics.
| FactSnippet No. 591,662 |
4.
Ketamine is an NMDA receptor antagonist and that accounts for most of its actions except the antidepressive effect, the mechanism of which is a matter of much research and debate.
| FactSnippet No. 591,663 |
5.
Ketamine was first synthesized in 1962 and approved for use in the United States in 1970.
| FactSnippet No. 591,664 |
6.
Ketamine is frequently used in severely injured people and appears to be safe in this group.
| FactSnippet No. 591,665 |
7.
Ketamine is an option in children, as the sole anesthetic for minor procedures or as an induction agent followed by neuromuscular blocker and tracheal intubation In particular, children with cyanotic heart disease and neuromuscular disorders are good candidates for ketamine anesthesia.
| FactSnippet No. 591,666 |
8.
Ketamine infusions are used for acute pain treatment in emergency departments and in the perioperative period in individuals with refractory pain.
| FactSnippet No. 591,667 |
9.
Ketamine is likely to be most beneficial for surgical patients when severe post-operative pain is expected and for opioid-tolerant patients.
| FactSnippet No. 591,668 |
10.
Ketamine is especially useful in the prehospital setting, due to its effectiveness and low risk of respiratory depression.
| FactSnippet No. 591,669 |
11.
Ketamine has similar efficacy to opioids in a hospital emergency department setting for management of acute pain and for control of procedural pain.
| FactSnippet No. 591,670 |
12.
Ketamine is a robust and rapid-acting antidepressant, although its effect is transient.
| FactSnippet No. 591,671 |
13.
Ketamine is sometimes used in the treatment of status epilepticus that has failed to adequately respond to standard treatments, although only limited evidence exists in its favor.
| FactSnippet No. 591,672 |
14.
Ketamine can be absorbed by many different routes due to both its water and lipid solubility.
| FactSnippet No. 591,673 |
15.
Ketamine was first synthesized in 1962 by Calvin L Stevens, a professor of chemistry at Wayne State University and a Parke-Davis consultant.
| FactSnippet No. 591,674 |
16.
Ketamine is under investigation for its potential in treating treatment-resistant depression.
| FactSnippet No. 591,675 |
17.
Ketamine appears not to produce sedation or anaesthesia in snails.
| FactSnippet No. 591,676 |