Loperamide, sold under the brand name Imodium, among others, is a medication used to decrease the frequency of diarrhea.
FactSnippet No. 870,813 |
Loperamide, sold under the brand name Imodium, among others, is a medication used to decrease the frequency of diarrhea.
FactSnippet No. 870,813 |
Loperamide is effective for the treatment of a number of types of diarrhea.
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Loperamide treatment is not used in symptomatic C difficile infections, as it increases the risk of toxin retention and precipitation of toxic megacolon.
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Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism.
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Loperamide is not recommended in the United Kingdom for use during pregnancy or by nursing mothers.
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Loperamide can be present in breast milk, and is not recommended for breast-feeding mothers.
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Loperamide is a substrate of P-glycoprotein; therefore, the concentration of loperamide increases when given with a P-glycoprotein inhibitor.
FactSnippet No. 870,819 |
Loperamide is capable of decreasing the absorption of some other drugs.
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Loperamide is an opioid-receptor agonist and acts on the µ-opioid receptors in the myenteric plexus of the large intestine.
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Loperamide taken with quinidine was found to produce respiratory depression, indicative of central opioid action.
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Loperamide has been shown to cause a mild physical dependence during preclinical studies, specifically in mice, rats, and rhesus monkeys.
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Loperamide hydrochloride was first synthesized in 1969 by Paul Janssen from Janssen Pharmaceutica in Beerse, Belgium, following previous discoveries of diphenoxylate hydrochloride and fentanyl citrate .
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Loperamide was originally marketed as Imodium, and many generic brands are sold.
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Loperamide has typically been deemed to have a relatively low risk of misuse.
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