19 Facts About Lung cancer

Lung cancer, known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.

Lung cancer carcinomas derive from transformed, malignant cells that originate as epithelial cells, or from tissues composed of epithelial cells.

In many people, the Lung cancer has already spread beyond the original site by the time they have symptoms and seek medical attention.

In smokers who work with asbestos, the risk of lung cancer is increased 45-fold compared to the general population.

Similar to many other cancers, lung cancer is initiated by either the activation of oncogenes or the inactivation of tumor suppressor genes.

Metastasis of lung cancer requires transition from epithelial to mesenchymal cell type.

Lung cancer can be an incidental finding, as a solitary pulmonary nodule on a chest radiograph or CT scan done for an unrelated reason.

The definitive diagnosis of lung cancer is based on the histological examination of the suspicious tissue in the context of the clinical and radiological features.

Lung cancer carcinomas are categorized by the size and appearance of the malignant cells seen by a histopathologist under a microscope.

Lung cancer staging is an assessment of the degree of spread of the cancer from its original source.

For individuals with high risk of developing lung cancer, computed tomography screening can detect cancer and give a person options to respond to it in a way that prolongs life.

Treatment for lung cancer depends on the cancer's specific cell type, how far it has spread, and the person's performance status.

Adjuvant chemotherapy for people with stage IB Lung cancer is controversial, as clinical trials have not clearly demonstrated a survival benefit.

Several drugs that target molecular pathways in lung cancer are available, especially for the treatment of advanced disease.

Worldwide, lung cancer is the most common cancer among men for both incidence and mortality, and among women has the third-highest incidence and second-highest mortality .

Lung cancer is the third-most common cancer in the UK, and it is the most common cause of cancer-related death .

Lung cancer was uncommon before the advent of cigarette smoking; it was not even recognized as a distinct disease until 1761.

Research directions for lung cancer treatment include immunotherapy, which encourages the body's immune system to attack the tumor cells, epigenetics, and new combinations of chemotherapy and radiotherapy, both on their own and together.

Some Lung cancer cells appear to exploit this by expressing PD-L1 in order to switch off T cells that might recognise them as a threat.