19 Facts About Major depression

Major depression significantly affects a person's family and personal relationships, work or school life, sleeping and eating habits, and general health.

Therapies associated with Major depression include interferons, beta-blockers, isotretinoin, contraceptives, cardiac agents, anticonvulsants, antimigraine drugs, antipsychotics, and hormonal agents such as gonadotropin-releasing hormone agonist.

Depression occurring after giving birth is called postpartum Major depression and is thought to be the result of hormonal changes associated with pregnancy.

Seasonal affective disorder, a type of Major depression associated with seasonal changes in sunlight, is thought to be triggered by decreased sunlight.

Pathophysiology of Major depression is not completely understood, but current theories center around monoaminergic systems, the circadian rhythm, immunological dysfunction, HPA-axis dysfunction and structural or functional abnormalities of emotional circuits.

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HPA-axis abnormalities have been suggested in Major depression given the association of CRHR1 with Major depression and the increased frequency of dexamethasone test non-suppression in people who are depressed.

Development of mental health services is minimal in many countries; Major depression is viewed as a phenomenon of the developed world despite evidence to the contrary, and not as an inherently life-threatening condition.

Most-studied form of psychotherapy for Major depression is CBT, which teaches clients to challenge self-defeating, but enduring ways of thinking and change counter-productive behaviors.

People with major depression are less likely to follow medical recommendations for treating and preventing cardiovascular disorders, further increasing their risk of medical complications.

Major depression is about twice as common in women as in men, although it is unclear why this is so, and whether factors unaccounted for are contributing to this.

The risk of major depression is increased with neurological conditions such as stroke, Parkinson's disease, or multiple sclerosis, and during the first year after childbirth.

Major depression was the leading cause of disease burden in North America and other high-income countries, and the fourth-leading cause worldwide as of 2006.

Term Major depression itself was derived from the Latin verb, meaning "to press down".

Major depression theorized that objective loss, such as the loss of a valued relationship through death or a romantic break-up, results in subjective loss as well; the depressed individual has identified with the object of affection through an unconscious, narcissistic process called the libidinal cathexis of the ego.

Major depression emphasized early life experiences as a predisposing factor.

New definitions of Major depression were widely accepted, albeit with some conflicting findings and views.

Similarly, Hungarian-American psychiatrist Thomas Szasz and others argue that Major depression is a metaphorical illness that is inappropriately regarded as an actual disease.

Some well-known contemporary people with possible Major depression include Canadian songwriter Leonard Cohen and American playwright and novelist Tennessee Williams.

Social stigma of major depression is widespread, and contact with mental health services reduces this only slightly.