Mescaline or mescalin is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
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10 Facts About Mescaline
2.
Mescaline was first isolated and identified in 1897 by the German chemist Arthur Heffter and first synthesized in 1919 by Ernst Spath.
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3.
Mescaline has a wide array of suggested medical usage, including treatment of alcoholism and depression, due to these disorders having links to serotonin deficiencies.
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4.
Mescaline is biosynthesized from tyrosine which, in turn, is derived from phenylalanine by the enzyme phenylalanine hydroxylase.
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5.
Mescaline was first synthesized in 1919 by Ernst Spath from 3, 4, 5-trimethoxybenzoyl chloride.
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6.
Mescaline induces a psychedelic state similar to those produced by LSD and psilocybin, but with unique characteristics.
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7.
Mescaline is produced when products of natural mammalian catecholamine-based neuronal signaling such as dopamine and noradrenaline are subjected to additional metabolism via methylation, and mescaline's hallucinogenic properties stem from its structural similarities with these two neurotransmitters.
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8.
Mescaline is known to have even greater binding affinity for the serotonin 5-HT2C receptor.
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9.
Mescaline is legal only for certain religious groups and in scientific and medical research.
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10.
Mescaline is considered a schedule 9 substance in Australia under the Poisons Standard.
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