Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to treat severe agitation.
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16 Facts About Midazolam
2.
Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek.
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3.
Midazolam was patented in 1974 and came into medical use in 1982.
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4.
Midazolam is sometimes used for the acute management of prolonged seizures.
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5.
Midazolam is effective for status epilepticus or when intravenous access cannot be obtained, and has advantages of being water-soluble, having a rapid onset of action and not causing metabolic acidosis from the propylene glycol vehicle, which occurs with other benzodiazepines.
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6.
Midazolam is superior to diazepam in impairing memory of endoscopy procedures, but propofol has a quicker recovery time and a better memory-impairing effect.
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7.
Midazolam is sometimes used in newborns who are receiving mechanical ventilation, although morphine is preferred, owing to its better safety profile for this indication.
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8.
Midazolam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel.
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9.
Midazolam is a short-acting benzodiazepine in adults with an elimination half-life of 1.
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10.
Midazolam is metabolised by cytochrome P450 enzymes and by glucuronide conjugation.
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11.
Midazolam is among about 35 benzodiazepines currently used medically, and was synthesized in 1975 by Walser and Fryer at Hoffmann-LaRoche, Inc in the United States.
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12.
Midazolam is becoming increasingly popular in veterinary medicine due to its water solubility.
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13.
Midazolam is available in the United States as a syrup or as an injectable solution.
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14.
Midazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
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