11 Facts About NFAT

One or more members of the NFAT family is expressed in most cells of the immune system.

NFAT is involved in the development of cardiac, skeletal muscle, and nervous systems.

NFAT was first discovered as an activator for the transcription of IL-2 in T cells but has since been found to play an important role in regulating many more body systems.

NFAT is being investigated as a drug target for several different disorders.

The reason for this is that it is activated through IL7R which leads to subsequent phosphorylation of single tyrosine in NFAT mediated by Jnk3 kinase a member of MAPK kinase subfamily.

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However, not every NFAT has the same significance for each subpopulation of T cells.

Each different class of NFAT contributes to different steps in the neural development.

NFAT is a known important player in both the developing and adult nervous system.

NFAT plays a role in the regulation of inflammation of inflammatory bowel disease.

NFAT plays a role in Rheumatoid Arthritis, an autoimmune disease that has a strong pro-inflammatory component.

CN inhibitors, which prevent the activation of NFAT, including CsA and tacrolimus, are used in the treatment of rheumatoid arthritis, multiple sclerosis, Crohn's disease, and ulcerative colitis and to prevent the rejection of organ transplants.