Nortriptyline, sold under the brand name Pamelor, among others, is a medication used to treat depression.
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10 Facts About Nortriptyline
2.
Nortriptyline is a less preferred treatment for ADHD and stopping smoking.
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4.
Nortriptyline has been used as an off-label treatment for Irritable Bowel Syndrome, or IBS.
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5.
Nortriptyline is a strong norepinephrine reuptake inhibitor and a moderate serotonin reuptake inhibitor.
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6.
Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver.
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7.
Nortriptyline is metabolized in the liver by the hepatic enzyme CYP2D6, and genetic variations within the gene coding for this enzyme can affect its metabolism, leading to changes in the concentrations of the drug in the body.
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8.
Nortriptyline is a tricyclic compound, specifically a dibenzocycloheptadiene, and possesses three rings fused together with a side chain attached in its chemical structure.
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9.
Nortriptyline is a secondary amine TCA, with its N-methylated parent amitriptyline being a tertiary amine.
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10.
Nortriptyline is the English and French generic name of the drug and its INN, BAN, and DCF, while nortriptyline hydrochloride is its USAN, USP, BANM, and JAN.
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