19 Facts About Oncolytic virus

An oncolytic virus is a virus that preferentially infects and kills cancer cells.

In 2015, talimogene laherparepvec, an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in the US and European Union, for the treatment of advanced inoperable melanoma.

Imlygic, an attenuated herpes simplex Oncolytic virus, has been genetically engineered to replicate preferentially within tumor cells and to generate antigens that elicit an immune response.

Since vaccinia virus has long been recognized as an ideal backbone for vaccines due to its potent antigen presentation capability, this combines well with its natural oncolytic activities as an oncolytic virus for cancer immunotherapy.

Vesicular stomatitis Oncolytic virus is a rhabdoOncolytic virus, consisting of 5 genes encoded by a negative sense, single-stranded RNA genome.

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The low pathogenicity of this Oncolytic virus is due in large part to its sensitivity to interferons, a class of proteins that are released into the tissues and bloodstream during infection.

Recent research has shown that this virus has the potential to cure brain tumours, thanks to its oncolytic properties.

PolioOncolytic virus is a natural invasive neurotropic Oncolytic virus, making it the obvious choice for selective replication in tumours derived from neuronal cells.

PolioOncolytic virus has a plus-strand RNA genome, the translation of which depends on a tissue-specific internal ribosome entry site within the 5' untranslated region of the viral genome, which is active in cells of neuronal origin and allows translation of the viral genome without a 5' cap.

The resulting PV1 Oncolytic virus was able to selectively destroy malignant glioma cells, while leaving normal neuronal cells untouched.

Reolysin is a formulation of reoOncolytic virus intended to treat various cancers currently undergoing clinical trials.

The potential use of echovirus as an oncolytic virus to treat cancer was discovered by Latvian scientist Aina Muceniece in the 1960s and 1970s.

However, several days later an investigative TV show revealed that State Agency of Medicines had run laboratory tests on the vials, and found that the amount of ECHO-7 Oncolytic virus is of a much smaller amount than claimed by the manufacturer.

Semliki Forest Oncolytic virus is a Oncolytic virus that naturally infects cells of the central nervous system and causes encephalitis.

The modified Oncolytic virus reduced tumour growth and prolonged survival of mice with brain tumours.

The modified Oncolytic virus was found to efficiently kill human glioblastoma tumour cell lines.

Maraba Oncolytic virus, first identified in Brazilian sandflies, is being tested clinically.

CoxsackieOncolytic virus A21 is being developed by Viralytics under trade name Cavatak.

In science fiction, the concept of an oncolytic virus was first introduced to the public in Jack Williamson's novel Dragon's Island, published in 1951, although Williamson's imaginary virus was based on a bacteriophage rather than a mammalian virus.