Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
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11 Facts About Oxidative stress
2.
Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione.
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3.
The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state.
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4.
Oxidative stress is suspected to be important in neurodegenerative diseases including Lou Gehrig's disease, Parkinson's disease, Alzheimer's disease, Huntington's disease, depression, and multiple sclerosis.
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5.
Oxidative stress is thought to be linked to certain cardiovascular disease, since oxidation of LDL in the vascular endothelium is a precursor to plaque formation.
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6.
Oxidative stress plays a role in the ischemic cascade due to oxygen reperfusion injury following hypoxia.
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7.
Oxidative stress contributes to tissue injury following irradiation and hyperoxia, as well as in diabetes.
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8.
Oxidative stress is likely to be involved in age-related development of cancer.
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10.
Under these conditions, the selective pressure of oxidative stress is thought to have driven the evolutionary transformation of an archaeal lineage into the first eukaryotes.
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11.
Oxidative stress might have acted in synergy with other environmental stresses to drive this selection.
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