11 Facts About PANDAS

Whether PANDAS was a distinct entity differing from other cases of tic disorders or OCD is debated.

Treatment for children suspected of PANDAS is generally the same as the standard treatments for Tourette syndrome and OCD.

In PANDAS, it is believed that tics and OCD are produced in a similar manner.

Whether the group of patients diagnosed with PANDAS have developed tics and OCD through a different mechanism than seen in other people diagnosed with TS is unclear.

PANDAS is mentioned in the World Health Organization's ICD-11, effective in 2022, under autoimmune central nervous system disorders, but diagnostic criteria are not defined and no specific code for PANS or PANDAS is given.

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Treatment for children suspected of PANDAS is generally the same as the standard treatments for TS and OCD.

Studies of experimental treatments for PANS and PANDAS are "few and in general have moderate or high risk of bias", according to a Sigra et al review published in 2018, which states:.

Debate surrounding the PANDAS hypothesis has societal implications; the media and the Internet have played a role in the PANDAS controversy.

PANDAS was first described in 1998 by Susan Swedo and a group of researchers at the US National Institute of Mental Health .

Michael Pichichero noted several reasons that PANDAS had not been validated as a disease classification.

CANS removes the requirement for GAS infection, allowing for multiple causes, which Singer proposed because of the "inconclusive and conflicting scientific support" for PANDAS, including "strong evidence suggesting the absence of an important role for GABHS, a failure to apply published [PANDAS] criteria, and a lack of scientific support for proposed therapies".