Phenylalanine is an essential a-amino acid with the formula HNO.
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11 Facts About Phenylalanine
2.
Phenylalanine is a precursor for tyrosine, the monoamine neurotransmitters dopamine, norepinephrine, epinephrine, and the skin pigment melanin.
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3.
L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids.
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4.
Phenylalanine uses the same active transport channel as tryptophan to cross the blood–brain barrier.
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5.
Phenylalanine is the starting compound used in the synthesis of flavonoids.
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Escherichia coli6.
Phenylalanine is converted to cinnamic acid by the enzyme phenylalanine ammonia-lyase.
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7.
DL-Phenylalanine is marketed as a nutritional supplement for its purported analgesic and antidepressant activities.
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8.
D-Phenylalanine is absorbed from the small intestine and transported to the liver via the portal circulation.
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9.
D-Phenylalanine is distributed to the various tissues of the body via the systemic circulation.
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10.
L-Phenylalanine is an antagonist at a2d Ca calcium channels with a Ki of 980 nM.
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11.
L-Phenylalanine is produced for medical, feed, and nutritional applications, such as aspartame, in large quantities by utilizing the bacterium Escherichia coli, which naturally produces aromatic amino acids like phenylalanine.
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