31 Facts About Raman spectroscopy


Raman spectroscopy is commonly used in chemistry to provide a structural fingerprint by which molecules can be identified.

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Raman spectroscopy relies upon inelastic scattering of photons, known as Raman scattering.

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Spontaneous Raman spectroscopy scattering is typically very weak; as a result, for many years the main difficulty in collecting Raman spectroscopy spectra was separating the weak inelastically scattered light from the intense Rayleigh scattered laser light .

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Name "Raman spectroscopy" typically refers to vibrational Raman using laser wavelengths which are not absorbed by the sample.

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The intensity of the Raman spectroscopy scattering is proportional to this polarizability change.

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Therefore, the Raman spectroscopy spectrum depends on the rovibronic states of the molecule.

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Raman spectroscopy effect is based on the interaction between the electron cloud of a sample and the external electric field of the monochromatic light, which can create an induced dipole moment within the molecule based on its polarizability.

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Raman spectroscopy won the Nobel Prize in Physics in 1930 for this discovery.

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Systematic pioneering theory of the Raman spectroscopy effect was developed by Czechoslovak physicist George Placzek between 1930 and 1934.

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Raman spectroscopy shifts are typically reported in wavenumbers, which have units of inverse length, as this value is directly related to energy.

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Where is the Raman spectroscopy shift expressed in wavenumber, is the excitation wavelength, and is the Raman spectroscopy spectrum wavelength.

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Raman spectroscopy scattered light is typically collected and either dispersed by a spectrograph or used with an interferometer for detection by Fourier Transform methods.

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FT–Raman spectroscopy is almost always used with NIR lasers and appropriate detectors must be used depending on the exciting wavelength.

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Raman spectroscopy is used in chemistry to identify molecules and study chemical bonding and intramolecular bonds.

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Raman spectroscopy is used to study the addition of a substrate to an enzyme.

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In solid-state physics, Raman spectroscopy is used to characterize materials, measure temperature, and find the crystallographic orientation of a sample.

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Raman spectroscopy can be used to observe other low frequency excitations of a solid, such as plasmons, magnons, and superconducting gap excitations.

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The orientation of an anisotropic crystal can be found from the polarization of Raman spectroscopy-scattered light with respect to the crystal and the polarization of the laser light, if the crystal structure's point group is known.

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In solid state chemistry and the bio-pharmaceutical industry, Raman spectroscopy can be used to not only identify active pharmaceutical ingredients, but to identify their polymorphic forms, if more than one exist.

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Raman spectroscopy has a wide variety of applications in biology and medicine.

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Raman spectroscopy has been used as a noninvasive technique for real-time, in situ biochemical characterization of wounds.

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Multivariate analysis of Raman spectroscopy spectra has enabled development of a quantitative measure for wound healing progress.

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Spatially offset Raman spectroscopy, which is less sensitive to surface layers than conventional Raman, can be used to discover counterfeit drugs without opening their packaging, and to non-invasively study biological tissue.

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Raman spectroscopy has been used in several research projects as a means to detect explosives from a safe distance using laser beams.

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Raman spectroscopy is an efficient and non-destructive way to investigate works of art and cultural heritage artifacts, in part because it is a non-invasive process which can be applied in situ.

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FT-Raman spectroscopy has been used with microscopes, typically in combination with near-infrared laser excitation.

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Raman scattering, specifically tip-enhanced Raman spectroscopy, produces high resolution hyperspectral images of single molecules, atoms, and DNA.

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Raman spectroscopy scattering is polarization sensitive and can provide detailed information on symmetry of Raman spectroscopy active modes.

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The Raman spectroscopy scattered light collected is passed through a second polarizer before entering the detector.

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Variants of normal Raman spectroscopy exist with respect to excitation-detection geometries, combination with other techniques, use of special optics and specific choice of excitation wavelengths for resonance enhancement.

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Morphologically Directed Raman Spectroscopy combines automated particle imaging and Raman microspectroscopy into a singular integrated platform in order to provide particle size, shape, and chemical identification.

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