15 Facts About Salvinorin A

Salvinorin A is the main active psychotropic molecule in Salvia divinorum.

Salvinorin A can produce psychoactive experiences in humans with a typical duration of action being several minutes to an hour or so, depending on the method of ingestion.

Salvinorin A is found with several other structurally related salvinorins.

Salvinorin A is a trans-neoclerodane diterpenoid with the chemical formula C23H28O8.

Unlike other known opioid-receptor ligands, salvinorin A is not an alkaloid, as it does not contain a basic nitrogen atom.

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Salvinorin A has no action at the 5-HT2A serotonin receptor, the principal molecular target responsible for the actions of 'classical' psychedelics such as LSD and mescaline.

Salvinorin A has been shown to have effect on cannabinoid CB1 receptors.

Salvinorin A is effectively deactivated by the gastrointestinal system, so alternative routes of administration must be used for better absorption.

Salvinorin A is under preliminary research for its possible use as a scaffold in medicinal chemistry to develop new drugs for treating psychiatric diseases, such as addiction from cocaine dependence.

SdCPS2 catalyzes the first committed reaction in the biosynthesis of salvinorin A by producing its characteristic clerodane scaffold.

Salvinorin A is one of several structurally related salvinorins found in the Salvia divinorum plant.

Salvinorin A is the only naturally occurring salvinorin that is known to be psychoactive.

Salvinorin A is sometimes regulated together with its host, Salvia divinorum, due to its psychoactive and analgesic effects.

Salvinorin A is not scheduled at the federal level in the United States.

Salvinorin A is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard.