Trazodone, sold under many brand names, is an antidepressant medication.
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26 Facts About Trazodone
3.
Trazodone has minimal anticholinergic activity, it was especially welcomed as a treatment for geriatric patients with depression when it first became available.
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4.
Trazodone is often used in the treatment of anxiety disorders such as generalized anxiety disorder, panic disorder, post-traumatic stress disorder, and obsessive–compulsive disorder.
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5.
Trazodone is often used as an alternative to benzodiazepines in the treatment of anxiety disorders.
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6.
Trazodone was the second-most prescribed agent for insomnia in the early 2000s, though most studies of trazodone for treatment of sleep disturbances have been in depressed individuals.
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7.
Trazodone is provided as the hydrochloride salt and is available in the form of 50mg, 100mg, 150mg, and 300mg oral tablets.
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8.
Trazodone is not recommended for use during the initial recovery phase of myocardial infarction.
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9.
Trazodone is associated with increased risk of falls in older adults.
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10.
Trazodone appears to be relatively safer than TCAs, MAOIs, and a few of the other second-generation antidepressants in overdose situations, especially when it is the only agent taken.
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11.
Trazodone is metabolized by several liver enzymes, including CYP3A4, CYP2D6, and CYP1A2.
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12.
Trazodone is a mixed agonist and antagonist of various serotonin receptors, antagonist of adrenergic receptors, weak histamine H1 receptor antagonist, and weak serotonin reuptake inhibitor.
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13.
Trazodone is a 5-HT1A receptor partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity.
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14.
Trazodone lacks any affinity for the muscarinic acetylcholine receptors, so does not produce anticholinergic side effects.
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15.
Trazodone is known to be extensively metabolized by the liver via hydroxylation, N-oxidation, and N-dealkylation.
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16.
Trazodone is a triazolopyridine derivative and a phenylpiperazine that is structurally related to nefazodone and etoperidone, each of which are derivatives of it.
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17.
Trazodone was developed in Italy, in the 1960s, by Angelini Research Laboratories as a second-generation antidepressant.
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18.
Trazodone was patented and marketed in many countries all over the world.
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19.
Trazodone is the generic name of the drug and its INN, BAN, and DCF, while trazodone hydrochloride is its USAN, USP, BANM, and JAN.
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20.
Trazodone has been marketed under a large number of brand names throughout the world.
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21.
Trazodone has been reported to be effective in the treatment of sleep apnea.
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22.
Trazodone has been studied as an adjunctive therapy in the treatment of schizophrenia.
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23.
Trazodone has been reported to be effective in treating antipsychotic-related extrapyramidal symptoms such as akathisia.
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24.
Trazodone has been studied and reported to be effective in the treatment of bulimia, but there is limited evidence to support this use.
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25.
Trazodone might be effective in the treatment of adjustment disorder.
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26.
Trazodone has been used to reduce anxiety and stress, to improve sleep, and to produce sedation in dogs and cats in veterinary medicine.
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