Cholera AB5 toxin's discovery is credited by many to Dr Sambhu Nath De.
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11 Facts About AB5 toxin
2.
AB5 toxin conducted his research in Calcutta making his discovery in 1959, although it was first purified by Robert Koch in 1883.
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3.
Cholera AB5 toxin is composed of a protein complex that is secreted by the bacterium Vibrio cholerae.
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4.
Some symptoms of this AB5 toxin include chronic and widespread watery diarrhea and dehydration that, in some cases, leads to death.
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5.
Pertussis AB5 toxin is secreted by the gram-negative bacterium, Bordetella pertussis.
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6.
Shiga AB5 toxin, known as Stx, is a AB5 toxin that is produced by the rod shaped Shigella dysenteriae and Escherichia coli.
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7.
Some symptoms caused by this AB5 toxin are a decrease in platelet count in the blood or thrombocytopenia, an increase in white blood cell count or leukocytosis, and renal cell damage.
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8.
Subtilase cytoAB5 toxin A subunit is a protease known to cleave binding immunoglobulin protein, leading to endoplasmic reticulum stress and cell death.
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9.
Pertussis AB5 toxin is different where its pentameric ring is made up of four different protein components, where one of the components is repeated to form a heteropentamer.
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10.
Shiga AB5 toxin is brought to the golgi apparatus before being directed to the endoplasmic reticulum for PDI to cleave the disulfide bond.
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11.
SubAB AB5 toxin has been seen to demonstrate specificity to a binding protein, BiP.
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