Cholera AB5 toxin's discovery is credited by many to Dr Sambhu Nath De.
FactSnippet No. 1,656,948 |
AB5 toxin conducted his research in Calcutta making his discovery in 1959, although it was first purified by Robert Koch in 1883.
FactSnippet No. 1,656,949 |
Cholera AB5 toxin is composed of a protein complex that is secreted by the bacterium Vibrio cholerae.
FactSnippet No. 1,656,950 |
Some symptoms of this AB5 toxin include chronic and widespread watery diarrhea and dehydration that, in some cases, leads to death.
FactSnippet No. 1,656,951 |
Pertussis AB5 toxin is secreted by the gram-negative bacterium, Bordetella pertussis.
FactSnippet No. 1,656,952 |
Shiga AB5 toxin, known as Stx, is a AB5 toxin that is produced by the rod shaped Shigella dysenteriae and Escherichia coli.
FactSnippet No. 1,656,953 |
Some symptoms caused by this AB5 toxin are a decrease in platelet count in the blood or thrombocytopenia, an increase in white blood cell count or leukocytosis, and renal cell damage.
FactSnippet No. 1,656,954 |
Subtilase cytoAB5 toxin A subunit is a protease known to cleave binding immunoglobulin protein, leading to endoplasmic reticulum stress and cell death.
FactSnippet No. 1,656,955 |
Pertussis AB5 toxin is different where its pentameric ring is made up of four different protein components, where one of the components is repeated to form a heteropentamer.
FactSnippet No. 1,656,956 |
Shiga AB5 toxin is brought to the golgi apparatus before being directed to the endoplasmic reticulum for PDI to cleave the disulfide bond.
FactSnippet No. 1,656,957 |
SubAB AB5 toxin has been seen to demonstrate specificity to a binding protein, BiP.
FactSnippet No. 1,656,958 |