12 Facts About Bacillus subtilis


Bacillus subtilis, known as the hay bacillus or grass bacillus, is a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants, humans and marine sponges.

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Bacillus subtilis has proven highly amenable to genetic manipulation, and has become widely adopted as a model organism for laboratory studies, especially of sporulation, which is a simplified example of cellular differentiation.

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In terms of popularity as a laboratory model organism, B subtilis is often considered as the Gram-positive equivalent of Escherichia coli, an extensively studied Gram-negative bacterium.

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Bacillus subtilis is a model organism used to study bacterial chromosome replication.

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Competence in B subtilis is induced toward the end of logarithmic growth, especially under conditions of amino-acid limitation.

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Antibiotic bacitracin was first isolated from a variety of Bacillus licheniformis named "Tracy I" in 1945, then considered part of the B subtilis species.

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Since the 1960s B subtilis has had a history as a test species in spaceflight experimentation.

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Wild-type natural isolates of B subtilis are difficult to work with compared to laboratory strains that have undergone domestication processes of mutagenesis and selection.

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Strain of B subtilis formerly known as Bacillus natto is used in the commercial production of the Japanese food natto, as well as the similar Korean food cheonggukjang.

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Bacillus subtilis was reviewed by the US FDA Center for Veterinary Medicine and found to present no safety concerns when used in direct-fed microbial products, so the Association of American Feed Control Officials has listed it approved for use as an animal feed ingredient under Section 36.

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Bacillus subtilis CU1 was evaluated in a 16-week study to healthy subjects.

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Bacillus subtilis has been granted "Qualified Presumption of Safety" status by the European Food Safety Authority.

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