12 Facts About Bacillus subtilis

Bacillus subtilis, known as the hay bacillus or grass bacillus, is a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants, humans and marine sponges.

Bacillus subtilis has proven highly amenable to genetic manipulation, and has become widely adopted as a model organism for laboratory studies, especially of sporulation, which is a simplified example of cellular differentiation.

In terms of popularity as a laboratory model organism, B subtilis is often considered as the Gram-positive equivalent of Escherichia coli, an extensively studied Gram-negative bacterium.

Bacillus subtilis is a model organism used to study bacterial chromosome replication.

Competence in B subtilis is induced toward the end of logarithmic growth, especially under conditions of amino-acid limitation.

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Antibiotic bacitracin was first isolated from a variety of Bacillus licheniformis named "Tracy I" in 1945, then considered part of the B subtilis species.

Since the 1960s B subtilis has had a history as a test species in spaceflight experimentation.

Wild-type natural isolates of B subtilis are difficult to work with compared to laboratory strains that have undergone domestication processes of mutagenesis and selection.

Strain of B subtilis formerly known as Bacillus natto is used in the commercial production of the Japanese food natto, as well as the similar Korean food cheonggukjang.

Bacillus subtilis was reviewed by the US FDA Center for Veterinary Medicine and found to present no safety concerns when used in direct-fed microbial products, so the Association of American Feed Control Officials has listed it approved for use as an animal feed ingredient under Section 36.

Bacillus subtilis CU1 was evaluated in a 16-week study to healthy subjects.

Bacillus subtilis has been granted "Qualified Presumption of Safety" status by the European Food Safety Authority.