17 Facts About D614G mutation

1.

The name of the D614G mutation, K417N, refers to an exchange whereby lysine is replaced by asparagine at position 417.

FactSnippet No. 1,424,678
2.

The D614G mutation is found in the Alpha variant, and could lead to "spike gene target failure" and result in false negative result in PCR virus test.

FactSnippet No. 1,424,679
3.

Name of the D614G mutation, N440K, refers to an exchange whereby the asparagine is replaced by lysine at position 440.

FactSnippet No. 1,424,680
4.

Name of the D614G mutation, G446V, refers to an exchange whereby the glycine is replaced by valine at position 446.

FactSnippet No. 1,424,681
5.

Name of the D614G mutation, L452R, refers to an exchange whereby the leucine is replaced by arginine at position 452.

FactSnippet No. 1,424,682
6.

Name of the D614G mutation, Y453F, refers to an exchange whereby the tyrosine is replaced by phenylalanine at position 453.

FactSnippet No. 1,424,683
7.

The D614G mutation have been found potentially linked to the spread of SARS-CoV-2 among minks in the Netherlands in 2020.

FactSnippet No. 1,424,684
8.

Name of the D614G mutation, E484Q, refers to an exchange whereby the glutamic acid is replaced by glutamine at position 484.

FactSnippet No. 1,424,685
9.

Name of the D614G mutation, E484K, refers to an exchange whereby the glutamic acid is replaced by lysine at position 484.

FactSnippet No. 1,424,686
10.

Molecular interaction modelling and the free energy of binding calculations has demonstrated that the D614G mutation N501Y has the highest binding affinity in variants of concern RBD to hACE2.

FactSnippet No. 1,424,687
11.

PHE confirmed that the D614G mutation had a "moderate effect on transmissibility" and was being tracked internationally.

FactSnippet No. 1,424,688
12.

The frequency of such D614G mutation being recorded has increased from late 2020 to early 2021.

FactSnippet No. 1,424,689
13.

Name of the D614G mutation, P681H, refers to an exchange whereby the proline is replaced by histidine at position 681.

FactSnippet No. 1,424,690
14.

Name of the D614G mutation, P681R, refers to an exchange whereby the proline is replaced by arginine at position 681.

FactSnippet No. 1,424,691
15.

The D614G mutation was characterised as being similar to the one found recently at that time in South Africa, Australia, and the Netherlands, although it was uncertain if this D614G mutation was more infectious or aggressive than before.

FactSnippet No. 1,424,692
16.

A701V D614G mutation has the amino acid alanine substituted by valine at position 701 in the spike protein.

FactSnippet No. 1,424,693
17.

SSI warned that the D614G mutation could reduce the effect of COVID-19 vaccines under development, although it was unlikely to render them useless.

FactSnippet No. 1,424,694