11 Facts About Dextromethorphan

Dextromethorphan is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines.

Dextromethorphan is available alone in the form of cough syrup and pills as well as in combination with other agents.

Dextromethorphan was once thought to cause Olney's lesions when administered intravenously; however, this was later proven inconclusive, due to lack of research on humans.

Dextromethorphan has been found to possess the following actions using rat tissues:.

Dextromethorphan is a prodrug of dextrorphan, which is the actual mediator of most of its dissociative effects through acting as a more potent NMDA receptor antagonist than dextromethorphan itself.

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Dextromethorphan is rapidly absorbed from the gastrointestinal tract and converted into the active metabolite dextrorphan in the liver by the cytochrome P450 enzyme CYP2D6.

Dextromethorphan undergoes N-demethylation, and partial conjugation with glucuronic acid and sulfate ions.

Dextromethorphan is the dextrorotatory enantiomer of levomethorphan, which is the methyl ether of levorphanol, both opioid analgesics.

Dextromethorphan is commonly available as the monohydrated hydrobromide salt, however some newer extended-release formulations contain dextromethorphan bound to an ion-exchange resin based on polystyrene sulfonic acid.

Dextromethorphan was approved by the FDA in 1958 as an over-the-counter antitussive.

Dextromethorphan usually provides its recreational effects in a non-linear fashion, so that they are experienced in significantly varied stages.