11 Facts About Dimethyl fumarate

Dimethyl fumarate is the methyl ester of fumaric acid and is named after the earth smoke plant .

Dimethyl fumarate combined with three other fumaric acid esters is solely licensed in Germany as an oral therapy for psoriasis .

In 2017, a new oral formulation of dimethyl fumarate was approved by the European Medicines Agency for use in the European Union as a treatment for moderate-to-severe plaque psoriasis.

Dimethyl fumarate is thought to have immunomodulatory properties without causing significant immunosuppression.

Dimethyl fumarate has been applied as a biocide in furniture or shoes to prevent growths of mold during storage or transport in a humid climates.

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Dimethyl fumarate is approved as a generic medication in the United States as of 2020.

In Germany, dimethyl fumarate is marketed for the treatment of psoriasis and is available as an oral formulation mixed with related compounds ; in the UK, it is available as a pure oral formulation .

Dimethyl fumarate is metabolised to monomethyl fumarate prior to entering systemic distribution.

In mice that lack Nrf2 expression dimethyl fumarate is still able to modulate the immune system, which indicates that Nrf2 is not required for its immunomodulatory action.

Dimethyl fumarate is an old compound used in industrial chemistry and can be purchased by the ton; as of 2012, one could purchase it for $1 to $50 per metric ton, with a two-ton minimum purchase.

Dimethyl fumarate has been found to be an allergic sensitizer at very low concentrations, producing eczema by contact allergy that is difficult to treat.