20 Facts About Diphenhydramine

Diphenhydramine is an antihistamine medication mainly used to treat allergies.

Diphenhydramine is a potent anticholinergic, and works as a deliriant at higher than recommended doses as a result.

Diphenhydramine was first made by George Rieveschl and came into commercial use in 1946.

Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms.

Diphenhydramine has local anesthetic properties, and has been used as such in people allergic to common local anesthetics such as lidocaine.

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Diphenhydramine is used to treat akathisia and Parkinson's disease–like extrapyramidal symptoms caused by antipsychotics.

Diphenhydramine has been used off prescription by parents in an attempt to make their children sleep or remain sedated on long-distance flights.

Diphenhydramine has antiemetic properties, which make it useful in treating the nausea that occurs in vertigo and motion sickness.

Diphenhydramine is not recommended for people older than 60 or children under the age of six, unless a physician is consulted.

Diphenhydramine is category B in the FDA Classification of Drug Safety During Pregnancy.

Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses.

Diphenhydramine is contraindicated in premature infants and neonates as well as people who are breastfeeding.

Diphenhydramine has additive effects with alcohol and other CNS depressants.

Diphenhydramine is one of the most commonly misused over-the-counter drugs in the United States.

Diphenhydramine has been shown to inhibit the reuptake of serotonin.

Diphenhydramine is metabolized by the cytochrome P450 enzymes CYP2D6, CYP1A2, CYP2C9, and CYP2C19.

Diphenhydramine was discovered in 1943 by George Rieveschl, a former professor at the University of Cincinnati.

Diphenhydramine is deemed to have limited abuse potential in the United States owing to its potentially serious side-effect profile and limited euphoric effects, and is not a controlled substance.

Diphenhydramine is among prohibited and controlled substances in the Republic of Zambia, and travelers are advised not to bring the drug into the country.

Diphenhydramine is marketed under the trade name Benadryl by McNeil Consumer Healthcare in the U S, Canada, and South Africa.