13 Facts About Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker class.

Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken by mouth.

Propranolol was patented in 1962 and approved for medical use in 1964.

Propranolol is not recommended for the treatment of high blood pressure by the Eighth Joint National Committee because a higher rate of the primary composite outcome of cardiovascular death, myocardial infarction, or stroke compared to an angiotensin receptor blocker was noted in one study.

Propranolol is occasionally used to treat performance anxiety, although evidence to support its use in any anxiety disorders is poor.

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Propranolol is being investigated as a potential treatment for PTSD.

Propranolol is classified as a competitive non-cardioselective sympatholytic beta blocker that crosses the blood–brain barrier.

Propranolol is a non-selective ß-adrenergic receptor antagonist, or beta blocker; that is, it blocks the action of epinephrine and norepinephrine at both ß1- and ß2-adrenergic receptors.

Propranolol is able to cross the blood–brain barrier and exert effects in the central nervous system in addition to its peripheral activity.

Propranolol is a highly lipophilic drug achieving high concentrations in the brain.

Propranolol was inspired by the early ß-adrenergic antagonists dichloroisoprenaline and pronethalol.

Propranolol is used by musicians, actors, and public speakers for its ability to treat anxiety symptoms activated by the sympathetic nervous system.

Propranolol was first marketed under the brand name Inderal, manufactured by ICI Pharmaceuticals, in 1965.