28 Facts About Sertraline

Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor class.

Sertraline is effective for panic disorder, social anxiety disorder, generalized anxiety disorder, and obsessive–compulsive disorder .

Sertraline taken during pregnancy is associated with a significant increase in congenital heart defects in newborns.

Sertraline was invented and developed by scientists at Pfizer and approved for medical use in the United States in 1991.

Sertraline is not approved for use in children except for those with OCD.

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Sertraline is an effective antidepressant in the routine clinical practice.

Sertraline improves the depression of dysthymic patients to a greater degree than psychotherapy.

Sertraline appears to work better in melancholic depression than fluoxetine, paroxetine, and mianserin and is similar to the tricyclic antidepressants such as amitriptyline and clomipramine.

Sertraline is equivalent to imipramine for the treatment of depression with co-morbid panic disorder, but it is better tolerated.

Sertraline used for the treatment of depression in elderly patients is superior to placebo and comparable to another SSRI fluoxetine, and tricyclic antidepressants amitriptyline, nortriptyline and imipramine.

Sertraline has much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurs more frequently with sertraline.

Sertraline is effective for the treatment of OCD in adults and children.

Sertraline is superior to placebo for the treatment of panic disorder.

Sertraline is equally effective for men and women, and for patients with or without agoraphobia.

Sertraline has been successfully used for the treatment of social anxiety disorder.

Sertraline has not been approved for the treatment of generalized anxiety disorder; however, several guidelines recommend it as a first-line medication referring to good quality controlled clinical trials.

Sertraline is effective in alleviating the symptoms of premenstrual dysphoric disorder, a severe form of premenstrual syndrome.

Sertraline is approved for the treatment of post-traumatic stress disorder .

Sertraline when taken daily can be useful for the treatment of premature ejaculation.

Sertraline is contraindicated in individuals taking monoamine oxidase inhibitors or the antipsychotic pimozide.

Sertraline concentrate contains alcohol and is therefore contraindicated with disulfiram.

Sertraline has a low level of exposure of an infant through the breast milk and is recommended as the preferred option for the antidepressant therapy of breast-feeding mothers.

Sertraline appears to be associated with microscopic colitis, a rare condition of unknown etiology.

Sertraline is a moderate inhibitor of CYP2D6 and CYP2B6 in vitro.

Sertraline had a slight inhibitory effect on the metabolism of diazepam, tolbutamide and warfarin, which are CYP2C9 or CYP2C19 substrates; the clinical relevance of this effect was unclear.

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Sertraline had no effect on the actions of digoxin and atenolol, which are not metabolized in the liver.

Sertraline asked another Pfizer chemist, Willard Welch, to synthesize some previously unexplored tametraline derivatives.

Sertraline was approved by the US Food and Drug Administration in 1991 based on the recommendation of the Psychopharmacological Drugs Advisory Committee; it had already become available in the United Kingdom the previous year.