Trp operon is a group of genes that are transcribed together, encoding the enzymes that produce the amino acid tryptophan in bacteria.
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10 Facts About Trp operon
2.
The trp operon was first characterized in Escherichia coli, and it has since been discovered in many other bacteria.
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3.
The Trp operon is regulated so that, when tryptophan is present in the environment, the genes for tryptophan synthesis are repressed.
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4.
Trp operon contains five structural genes: trpE, trpD, trpC, trpB, and trpA, which encode the enzymes needed to synthesize tryptophan.
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5.
The trp operon additionally uses attenuation to control expression of the operon, a second negative feedback control mechanism.
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6.
Trp operon is well-studied and is commonly used as an example of gene regulation in bacteria alongside the lac operon.
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7.
The repressor for the trp operon is produced upstream by the trpR gene, which is constitutively expressed at a low level.
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8.
At the beginning of the transcribed genes of the trp operon is a sequence of at least 130 nucleotides termed the leader transcript .
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9.
The end result is that the operon will be transcribed only when tryptophan is unavailable for the ribosome, while the trpL transcript is constitutively expressed.
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10.
Trp operon genes are arranged in the same order in E coli and Bacillus subtilis.
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