14 Facts About Zopiclone

Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping.

Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone.

Zopiclone is recommended to be taken on a short-term basis, usually no more than a week or two.

Zopiclone is used for the short-term treatment of insomnia where sleep initiation or sleep maintenance are prominent symptoms.

Zopiclone reduces both delta waves and the number of high-amplitude delta waves whilst increasing low-amplitude waves.

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Zopiclone reduces the total amount of time spent in REM sleep as well as delaying its onset.

Zopiclone is less selective to the a1 site and has higher affinity to the a2 site than zaleplon.

Zopiclone is partly extensively metabolized in the liver to form an active N-demethylated derivative and an inactive zopiclone-N-oxide.

Zopiclone was developed and first introduced in 1986 by Rhone-Poulenc S A, now part of Sanofi-Aventis, the main worldwide manufacturer.

Zopiclone, as traditionally sold worldwide, is a racemic mixture of two stereoisomers, only one of which is active.

Zopiclone is currently available off-patent in a number of European countries, as well as Brazil, Canada, Hong Kong, and New Zealand.

Zopiclone has the potential for non-medical use, dosage escalation, and drug dependence.

Zopiclone has crosstolerance with barbiturates and is able to suppress barbiturate withdrawal symptoms.

Zopiclone is in the top ten medications obtained using a false prescription in France.