16 Facts About Paracetamol

Paracetamol, known as acetaminophen, is a medication used to treat fever and mild to moderate pain.

Paracetamol is effective for post-surgical pain, but it is inferior to ibuprofen.

Paracetamol is often used in patients who cannot tolerate NSAIDs like ibuprofen.

Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand.

Paracetamol is available as a generic medication, with brand names including Tylenol and Panadol among others.

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Paracetamol offered no benefit in the treatment of dengue fever and was accompanied by a higher rate of liver enzyme elevation: a sign of a potential liver damage.

Paracetamol is used for the relief of mild to moderate pain such as headache, muscle aches, minor arthritis pain, toothache as well as pain caused by cold, flu, sprains, and dysmenorrhea.

Paracetamol toxicity is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand.

Paracetamol appears to exert its effects through two mechanisms: the inhibition of cyclooxygenase and actions of its metabolite AM404.

Paracetamol is metabolized primarily in the liver, mainly by glucuronidation and sulfation, and the products are then eliminated in the urine .

Paracetamol was first marketed in the United States in 1950 under the name Triagesic, a combination of paracetamol, aspirin, and caffeine.

Paracetamol is the Australian Approved Name and British Approved Name as well as the international nonproprietary name used by the WHO and in many other countries; acetaminophen is the United States Adopted Name and Japanese Accepted Name and the name generally used in Canada, Venezuela, Colombia, and Iran.

Paracetamol is combined with other opioids such as dihydrocodeine, referred to as co-dydramol, oxycodone or hydrocodone.

Paracetamol is extremely toxic to cats, which lack the necessary UGT1A6 enzyme to detoxify it.

Paracetamol has been reported to be as effective as aspirin in the treatment of musculoskeletal pain in dogs.

Paracetamol is lethal to snakes, and has been suggested as a chemical control program for the invasive brown tree snake in Guam.