28 Facts About Smallpox vaccine

1.

Smallpox vaccine is the first vaccine to be developed against a contagious disease.

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2.

Term vaccine derives from the Latin word for cow, reflecting the origins of smallpox vaccination.

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3.

The origins of the smallpox vaccine became murky over time, especially after Louis Pasteur developed laboratory techniques for creating vaccines in the 19th century.

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4.

Allan Watt Downie demonstrated in 1939 that the modern smallpox vaccine was serologically distinct from cowpox, and vaccinia was recognized as a separate viral species.

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5.

From 1796 to the 1880s, the Smallpox vaccine was transmitted from one person to another through arm-to-arm vaccination.

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6.

Smallpox vaccine was successfully maintained in cattle starting in the 1840s, and calf lymph vaccine became the leading smallpox vaccine in the 1880s.

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7.

Egg-based Smallpox vaccine was used widely in Brazil, New Zealand, and Sweden, and on a smaller scale in many other countries.

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8.

ACAM2000 is a vaccine developed by Acambis, which was acquired by Sanofi Pasteur in 2008, before selling the smallpox vaccine to Emergent Biosolutions in 2017.

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9.

MVA-BN is a Smallpox vaccine manufactured by Bavarian Nordic by growing MVA in cell culture.

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10.

In May 2007, the Vaccines and Related Biological Products Advisory Committee of the U S Food and Drug Administration voted unanimously that a new live virus vaccine produced by Acambis, ACAM2000, is both safe and effective for use in persons at high risk of exposure to smallpox virus.

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11.

Smallpox vaccine's returned to London and had her daughter variolated in 1721 by Charles Maitland, during an epidemic of smallpox.

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12.

William Woodville, one of the early vaccinators and director of the London Smallpox Hospital is thought to have contaminated the cowpox matter – the vaccine – with smallpox matter and this essentially produced variolation.

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13.

Smallpox vaccine observed that people who caught cowpox while working with cattle were known not to catch smallpox.

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14.

Smallpox vaccine concluded that cowpox inoculation was a safe alternative to smallpox inoculation, but rashly claimed that the protective effect was lifelong.

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15.

The Smallpox vaccine was not carried in the form of flasks, but in the form of 22 orphaned boys, who were 'carriers' of the live cowpox virus.

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16.

Smallpox vaccine attracted a certain amount of local criticism and ridicule at the time then interest waned.

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17.

Smallpox vaccine thought vaccination offered no advantage over variolation, but maintained friendly contact with Jenner and certainly made no claim of priority for vaccination when critics attacked Jenner's reputation.

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18.

However, he was the first to publish his evidence and distribute Smallpox vaccine freely, provide information on selection of suitable material, and maintain it by arm-to-arm transfer.

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19.

Charles Creighton believed that uncontaminated Smallpox vaccine itself was a cause of syphilis.

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20.

Smallpox vaccine was the only vaccine available during this period, and so the determined opposition to it initiated a number of vaccine controversies that spread to other vaccines and into the 21st century.

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21.

Sydney Arthur Monckton Copeman, an English Government bacteriologist interested in smallpox vaccine investigated the effects on the bacteria in it of various treatments, including glycerine.

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22.

Smallpox vaccine later reported that glycerine killed the causative organisms of erysipelas and tuberculosis when they were added to the vaccine in "considerable quantity", and that his method was widely used on the continent.

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23.

Unfortunately glycerolated Smallpox vaccine soon lost its potency at ambient temperatures which restricted its use in tropical climates.

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24.

English Smallpox vaccine was occasionally made in sheep during World War I but from 1946 only sheep were used.

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25.

Smallpox vaccine was inoculated by scratches into the superficial layers of the skin, with a wide variety of instruments used to achieve this.

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26.

Smallpox vaccine was eradicated by a massive international search for outbreaks, backed up with a vaccination program, starting in 1967.

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27.

Origin of the modern smallpox vaccine has long been unclear, but horsepox was identified in the 2010s as the most likely ancestor.

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28.

Vaccination, the term which soon replaced cowpox inoculation and Smallpox vaccine inoculation, was first used in print by Jenner's friend, Richard Dunning in 1800.

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