15 Facts About Adalimumab

1.

Adalimumab, sold under the brand name Humira, among others, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis.

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2.

Adalimumab is a disease-modifying antirheumatic drug and monoclonal antibody that works by inactivating tumor necrosis factor-alpha.

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3.

Adalimumab was approved for medical use in the United States in 2002.

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4.

Adalimumab has been shown to reduce the signs and symptoms of moderate to severe rheumatoid arthritis in adults.

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5.

Adalimumab has been shown to reduce the signs and symptoms of, and is approved for treatment for, ankylosing spondylitis in adults.

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6.

Adalimumab has been shown to reduce the signs and symptoms of moderate to severe Crohn's disease.

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7.

Adalimumab has been shown to be effective therapy when used either continuously or intermittently in patients with moderate to severe psoriasis.

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8.

Adalimumab has been shown to reduce the signs and symptoms of moderate to severe polyarticular juvenile idiopathic arthritis in children aged four years and older.

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9.

Adalimumab is indicated for the treatment of non-infectious uveitis.

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10.

Adalimumab was the first fully human monoclonal antibody approved by the US Food and Drug Administration.

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11.

Adalimumab was discovered as a result of a collaboration between BASF Bioresearch Corporation and Cambridge Antibody Technology, UK, itself a collaboration of the government-funded Medical Research Council and three academics, which began in 1993.

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12.

Adalimumab, sold under the brand name Humira, was approved for use in the United States in 2002.

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13.

Adalimumab, sold under the brand names Humira and Trudexa, was approved for use in the European Union in September 2003.

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14.

Adalimumab biosimilars became available in the European Union in 2018, allowing the National Health Service to make record-breaking cost-savings, as this is the single most expensive drug used in NHS hospitals, costing more than £400million a year for about 46,000 patients.

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15.

In June 2020, a class action lawsuit filed by United Food and Commercial Workers Local 1500 against AbbVie, alleging that the drug manufacturer used a patent thicket over 100 strong to maintain a monopoly on Adalimumab, was dismissed by the Northern District Court in Illinois.

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