12 Facts About Lisuride

Lisuride, sold under the brand name Dopergin among others, is a monoaminergic medication of the ergoline class which is used in the treatment of Parkinson's disease, migraine, and high prolactin levels.

Lisuride is used to lower prolactin and, in low doses, to prevent migraine attacks.

Lisuride is a ligand of dopamine, serotonin, and adrenergic receptors as well as the histamine H1 receptor.

Lisuride is a partial agonist of the D2, D3, D4, 5-HT2A, 5-HT2C, 5-HT5A, and H1 receptors, a full or near-full agonist of the 5-HT1A, 5-HT1B, and 5-HT1D receptors, and a silent antagonist of the 5-HT2B receptor and a1A-, a2A-, a2B-, and a2C-adrenergic receptors.

Lisuride behaves as an agonist at the 5-HT2A receptor monomer.

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Lisuride dose-dependently suppresses prolactin levels due to its dopaminergic activity.

Lisuride is described as the free base and as the hydrogen maleate salt.

Lisuride was synthesized by Zikan and Semonsky at the Research Institute for Pharmacy and Biochemistry at Prague as an antimigraine agent analogous to methysergide and was described in 1960.

Lisuride has been sold under brand names including Arolac, Cuvalit, Dopagon, Dopergin, Dopergine, Eunal, Lisenil, Lizenil, Lysenyl, Proclacam, Prolacam, and Revanil.

Lisuride was previously more widely available throughout the world, but as of 2020 it appears to be marketed only in Egypt, France, Italy, Kuwait, Lebanon, Mexico, New Zealand, and Pakistan.

Lisuride is not currently available in the United States, as the drug was not a commercial success in comparison with other dopamine receptor agonists.

Lisuride was under development as a transdermal patch and subcutaneous implant for the treatment of Parkinson's disease, restless legs syndrome, and dyskinesias in the 2000s and 2010s, but development was discontinued.